Preservation of Organs for Transplant Research Paper - 1

Preservation of Organs for Transplant - Research Paper Example Sodiumpump regulates and reduces intracellular sodium under normothermic conditions, however, when the pump speed falls during hypothermia, the intracellular sodium rises, thus pulling water into the cell leading to lethal cell swelling (Toledo-Pereyra, 42). Methods With the modern technologies, some organs such as the liver can be stored for a longer periodthrough flushing the tissues or applying organ preservation fluids and preserving the tissues at (0–5Â ° C) hypothermic temperatures. This method is efficient as it uses various impairmentagents such as lactobionic acid, raffinose, hydroxyethyl glucose that prevent swelling of the cells during storage, and because the solution contains glutathione and adenosine agents that trigger normal metabolism function upon reperfusion by triggering generation high-energy phosphate (adenosine) upon reperfusion. Since the development of the UW solution, other preservation solutions have been discovered, which include Histidine-Tryptoph ane-Ketoglutarate (HTK) and Celsior. However, some Percentages of organs such as livers, kidneys and intrathoracic organs fail upon transplant hence need for improved methods for preservation.Bottom of Form Dynamic preservation methods require some dynamic fluid or gas movement to allow preservation. In the 20th century, Hypothermic machine perfusion was invented for organ preservation to extend both preservation time and quality. Alexis Carrel coined the term organ culture referring to an analogous technique for whole organs that would be developed by using vascular perfusion with support of Charles Lindbergh who helped with the engineering in which he developed a glass perfusion pump that could support kidneys by maintaining oxygen delivery through perfusion. Hypothermic... This paper stresses that in many years following the first successful transplantation of organs, preservation of tissues and organs has attained incredible successes in enhancing and improving preservation and function of organs, and irrespective of these improvements, a huge disparity still exists among the number of people on the waiting list and the available organs donors. The main organ preservation challenge will be how to enhance the marginal donor organs recovery and resuscitation mainly the donation after cardiac organ death; therefore, given the success of static organ preservation methods, the dynamic preservation methods, oxygen persufflation methods and other methods, there is a crucial advances in improving the donor problems. The author of the paper talks that dynamic preservation methods require some dynamic fluid or gas movement to allow preservation. In the 20th century, Hypothermic machine perfusion was invented for organ preservation to extend both preservation ti me and quality. This report makes a conclusion that hypothermic machine perfusion allows organs oxidation for ATP creation through fluid perfusion for oxygen transportation. The cold tissues oxygen requirements are low thus the oxygen demand is also low and this allows for slow flow rates during hypothermia and the relatively low oxygen carrying capacity of most crystalloid perforates are adequate at low temperatures.